by Institute for Personalized Medicine | Aug 22, 2017 | Bredesen Papers
Abstract Cognitive decline is a major concern of the aging population, and Alzheimer’s disease is the major cause of age-related cognitive decline, with approximately 5.4 million American patients and 30 million affected globally[1]. In the absence of effective...
by Institute for Personalized Medicine | Aug 22, 2017 | Bredesen Papers
Abstract Alzheimer’s disease is now the third leading cause of death in the United States, following only cardiovascular disease and cancer [1]. There are approximately 5.2 million Americans with AD, but this estimate ignores the many young Americans destined...
by Institute for Personalized Medicine | Aug 22, 2017 | Bredesen Papers
Abstract Alzheimer’s disease represents a major healthcare problem, with over five million Americans estimated to suffer from this disease, and a recent study showing that AD has now become the third leading cause of death, trailing only cardiovascular disease and...
by Institute for Personalized Medicine | Aug 22, 2017 | Bredesen Papers
Abstract Key Alzheimer’s disease-related protein may be a transcriptional regulator. The allele apolipoprotein E c4 (APOE £4) is the greatest genetic risk factor for Alzheimer’s disease (AD), but the role of the ApoE4 protein in AD has long been elusive. Turns out,...
by Institute for Personalized Medicine | Aug 22, 2017 | Bredesen Papers
Abstract A major unanswered question in biology and medicine is the mechanism by which the product of the apolipoprotein E ! 4 allele, the lipid-binding protein apolipoprotein E4 (ApoE4), plays a pivotal role in processes as disparate as Alzheimer’s disease (AD; in...