Abstract
Key Alzheimer’s disease-related protein may be a transcriptional regulator.
The allele apolipoprotein E c4 (APOE £4) is the greatest genetic risk factor for Alzheimer’s disease (AD), but the role of the ApoE4 protein in AD has long been elusive. Turns out, ApoE4 may function as a transcription factor, according to a study published today (January 20) in the The Journal of Neuroscience, led by investigators at the Buck Institute for Aging Research and the University of California, Los Angeles (UCLA).